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Lesley

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Reply with quote  #1 
but apparently my scans came back from the east coast, and my lung nodules grew slightly, I have new spots on my liver, and I forget where else...apparently some stuff shrank and new stuff grew...so I am set to get the Parp-i on Friday...along with the gem carbo...

I am in shock, I really thought it would be good news...this crap is determined to take me out isnt it?
nosurrender

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Reply with quote  #2 
Dear Lesley,
I am so sorry some of the things got bigger...
You are going to be fighting this SOB with the best stuff out there- I am glad you are starting the PARP so soon.
"Some stuff shrank"  means you ARE responding - the PARP can come in and knock out the rest of it.
Dr. Cliff Hudis of MSK doesn't get over excited about new things- but he said that PARP is changing TNBC mets treatment from "management" to SURVIVING IT.

I can only imagine how freaked out you are. But they are so optimistic about this new regimen, I pray that this will help you and you become stable then NED.

Big hugs and lots of love to you,
g


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Lesley

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Reply with quote  #3 
thank you Gina, for always posting on my posts, and making me feel better,..

did that doctor really say that?  I'll take any sliver of hope...


Lesley
delphinus

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Reply with quote  #4 
(((Lesley))) I second what Gina says...

It sounds like you had a "differential response". For the purposes of the trial they call it progression,  but really it is better news than if you had progressed across the board--something was working, but now, even better, you have THE BEST combo coming your way with adding the PARPi!

xoxox
love
janet

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Reply with quote  #5 
Dear Lesley- BE HOPEFUL!

The Reviews Are in:
Blockbuster drug known as PARP = A future of hope

"I believe that in the next two to three years, PARP inhibitors will do for triple-negative breast cancer what trastuzumab [Herceptin] did for HER2 breast cancer." Jenny Chang, Baylor


"This development may have the potential to change patient survival . . . and appears to potentially change the natural history of at least a subclass of metastatic breast cancer [TNBC]" Clifford Hudis, MSK

 
“When you go home, be excited. Be really excited about this. Tell your patients there is reason to be hopeful.” Eric Winer, Dana Farber


Until now, the treatment for triple negative breast cancer has been limited. The options for metastatic patients were few and far between. Until now. The first completed studies of PARP, have shown that not only does it slow progression of disease, but patients are experiencing a complete response to the drug.

The side effects of PARP are generally well tolerated and do not include hair loss.

Where once there was no hope, no magic drug for triple negative patients, PARP is proving itself to be, as Dr. Jenny Chang, of the Baylor School of Medicine said, “What Herceptin did for HER2 breast cancer.”

“Many experts have argued that it is not possible to change survival in stage IV breast cancer. Certainly now there evidence for an alternative viewpoint; that with the use of very effective drugs, we can change overall survival, and we should aim for that." Clifford Hudis, MSK

Sources:
Chang C.  Interview with Neil Love.  in Conversations with Oncology  Investigators - Bridging the Gap between Research and Patient Care.  Breast Cancer Update 2009;8(6):3-6 [Track 5; with audio].

Hudis C.  Interview by L Scott Zoeller 2009 Oct 21.  Extended Survival With PARP Inhibitors Changes Expectations in Metastatic Breast Cancer.  Viewpoints.  In OncologySTAT 2009.


Carlson R.  PARP Inhibitors Show Promise Against Metastatic Triple-Negative Breast Cancer in Early Studies.  Oncol Times 2009;31(15):10-11.


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Calico

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Reply with quote  #6 
awww...Lesley,
here is to the parp knocking this beast on it's behind for good...some stuff shrunk is GOOD!!!!
Glad you don't have to wait!!!


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