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nosurrender

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Reply with quote  #1 
Please see our blog post about this very important information

http://nosurrenderbreastcancer.blogspot.com/2015/08/use-caution-with-supplements-during.html

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Calico

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Reply with quote  #2 
I was eating blueberries (bought huge frozen bag) by the pounds each day and my radiation onc told me to stop because she was worried I'm keeping cancer alive too [wink] 

Best to keep it 'plain'

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edge

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Calico, Gina:

A Dissenting Voice

I would uncategorically dispute any claim made - for which no evidence is cited, as none is available - that consumption of berries regardless of level could potentially enhance cancer development or growth. This is unwarranted and unsubstantiated, and in contradiction of the best systematically reviewed and critically appraised data to date [1-5]. 

Berries, especially through most active inhibitory compound, the anthocyanins, have demonstrated potential to  inhibit carcinogenesis via reduction of the proliferation rate of premalignant cells, while also inhibiting angiogenesis and inflammation, exerting pro-apoptotic activity and both cell differentiation and adhesion, with genome-wide effects on the corresponding gene expressions controlling these functions, and preclinical along with some recent clinical data has found that berries can inhibit cancer development of the colon, the  esophagus, colon, the oral cavity (even when applied topically), and the mammary glands (see selective references below), with no evidence of clinically significant side effects or adverse interactions (pharmacokinetics).

To conclude, I would agree - based also on my own review and critical appraisal of the cumulative evidence to date - with the conclusion drawn by expert Gary Stoner at Ohio State University [5] that:

"It seems reasonable to suggest that berries be part of the daily diet, and that in individuals at high risk, the daily consumption of several grams of berry powder could well elicit protection."

In both these case (berries) and the recent flurry of premature cautions issued against co-consumption of omega-3 fatty acids and chemotherapy - which I dispute both here on No Surrender in my CAM forum

(at: http://www.nosurrenderbreastcancersupportforum.com/post/show_single_post?pid=1289472887&postcount=1)

as well as a posted response on the peer-reviewed Cancer Network (home of the Oncology journal), at:

http://www.cancernetwork.com/news/fish-oil-consumption-linked-chemoresistance#comment-39548)

- the data when critically reviewed simply to not support a clinically relevant contraindication in the human context for either of these CAM agents of considerable potential benefit in oncology.

 

References

  1. Stoner GD, Wang LS, Casto BC. Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries. Carcinogenesis 2008; 29(9):1665-74.
  2. Johnson SA, Arjmandi BH. Evidence for anti-cancer properties of blueberries: a mini-review. Anticancer Agents Med Chem 2013; 13(8):1142-8.
  3. Suh N, Pezzuto JM. Strawberry fields forever? Cancer Prev Res (Phila) 2012; 5(1):30-3.
  4. Stoner GD. Foodstuffs for preventing cancer: the preclinical and clinical development of berries. Cancer Prev Res (Phila) 2009; 2(3):187-94.
  5. Stoner GD, Wang L-S, Sardo C, et al. Cancer Prevention with Berries: Role of Anthocyanins. In JA Milner, DF Romagnolo (eds). Bioactive Compounds and Cancer Nutrition and Health. Humana Press. Springer Sciience+Business Media, LLC  2010: 703-723.
nosurrender

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Reply with quote  #4 
Hello Cali and Edgy
I am not advocating that people stop eating  a healthy diet during treatment. The article posted was about levels of Omega 3 supplementation having some effect on chemotherapy potency.
I believe in berries! I believe in asparagus! I believe in Calico and Edge!! [smile]

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Calico

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Reply with quote  #5 
Hi Gina and Edgy,
Thank you for the review.
Perhaps in 2005 they were not aware of these facts.
I love berries and need to up my intake, start living healthy.
Always more motivated to do so with evidence based reviews [smile]

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edge

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Reply with quote  #6 

Gina, Calico:


An Apology

No imputation was implied - I was critically appraising the claims - as I always do here - being made, not those posting the claims, and certainly not anyone just reporting what others are claiming, such as Calico and yourself, Dr. Markham or anyone else. My apologies if any implication of my recent postings in this connection appeared accusatory; that was certainly not my intent.

A Clarification

My point re berry consumption was to counter any false concern raised by a warrantless, evidence-free statement made by the radiation oncologist Calico happen to cite in passing. And  my point re omega-3 supplementation was to demonstrate that the widely-reported and repeated claim that the cited studied demonstrates that such supplementation adversely interacts with platinum-based chemotherapy is:

 

  1. fallacious, founded on limited and questionable preclinical data, and against the aggregated human clinical evidence to date;
  2. is further contradicted by epidemiological evidence;
  3. that  the study promoting the claim is significantly methodologically compromised to such degree as to be insufficiently powered to draw that, or any, conclusion re platinum agent to omega-3 supplementation adverse pharmacokinetics;
  4. that from a methodologically compromised study inconsistent with both human clinical and observational data, no conclusion of any clinical relevance can be derived.


From these collectively, therefore, we have no reason to doubt the pharmacokinetic safety of  omega-3 and chemotherapy co-consumption, and no valid safety signal has been raised to advise any special caution, let alone  contraindication.  

 

The Deeper Problem: Bias in Pharmacokinetic Reporting of Drug-Drug Interactions

I note that ondansetron (Zofran) a widely used agent for controlling chemotherapy-induced nausea and vomiting (CINV), cimetidine (Tagamet) a common antiacid, and phenytoin (Dilantin) a common anti-seizure agent, have all been documented to interfere with platinum agents used in oncology, and these plus diuretics like hydrochlorothiazide, anticonvulsants / neuroleptics for seizure disorders, ACE inhibitors and antihypertensives, benzodiazepines for anxiety and sleep disorders, antidepressants, anticoagulants like warfarin, among dozens of other categories of traditional drugs all have known potential for adverse drug-drug interactions (DDIs) when concurrent with a wide variety of oncology agents. And it is not only that traditional DDI's (drug-drug interactions across conventional medicines) can compromise the efficacy of oncology drugs, but they can even lead to significant numbers of deaths: a large retrospective study analyzed all deaths that occurred in a Norwegian hospital during 2 years in order to evaluate how often deaths resulted from adverse drug reactions. They found that about 29 of the cancer-related deaths were likely to involve a severe DDI [1].

 

With fully one-third of cancer outpatients at risk of significant adverse drug-drug interactions (DDIs) [2], I never cease to be amazed at the asymmetric nature of drug interaction warnings: I know dozens of patients who have already (in just days) been told to avoid omega-3 intake during active chemotherapy despite the lack of any supporting high methodology data and despite the fact of clear human clinical and observational data to the contrary, but I ask you, when was the last time any oncologist asked a cancer patient about whether they were taking any of the above classes of agents, let alone issued a contraindicative warning against any such agent, despite hundreds of studies documenting the significant potential for harm and compromise? The warnings are invariably reserved for natural agents [3].

What they fail to do is not objective science.

Looking Forward

So I will continue to expose the flaws in reported medical studies and their conclusions as a public service to the patient community here and elsewhere, and in that vein I will shortly be taking up the recent -and falsely reasoned - injunctions against using calcium supplements to reduce the risk of fractures, and their (falsely) claimed cardiovascular harms.

What I do is objective science.

 

And thanks Gina and Calico, two extraordinary souls and fellow warriors, for your kind appreciation and confidence.

(But ASPARAGUS!!!)

 

Selective References

1.    Buajordet I, Ebbesen J, Erikssen J, et al. Fatal adverse drug events: the paradox of drug treatment. J Intern Med 2001;250:327-341.

2.    Riechelmann RP, Del Giglio A. Drug interactions in oncology: how common are they? Ann Oncol 2009; 20: 1907–1912.

3.    Kaniklidis C. Drug Interactions in Oncology. [pending publication; available in pre-pub form under "Contributions" at the ResearchGate profile: https://www.researchgate.net/profile/Constantine_Kaniklidis].

nosurrender

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Reply with quote  #7 
We are so lucky to have you on our side Edgy!!!!!
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Calico

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Reply with quote  #8 
I agree [smile]

Back in 2005 the docs did what they knew best, going by the book.

I am very happy to have the knowledge from your research, to complement all my treatments. I truly appreciate your research and deciphering the facts for us into digestible bites [wink]

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