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FLLoriK

Angel
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Reply with quote  #1 
So the verdict is on: My breast cancer has mets to the lymph nodes around my lung, besides liver and bone mets and the suggestion for treatment is
Ixempra and tomoxifen.
Any info on each would be greatly appreciated.
nosurrender

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Reply with quote  #2 
I am SO SORRY LORI.
THIS TOTALLY SUCKS

I know there is such good things being said about Ixempra right now. I will email Edge and have him give you the lowdown on it.

I am sending you a HUGE HUG.

Oh my friend, you do NOT need this- DAMN THIS DISEASE!!!!

Love,
g


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Bren

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Reply with quote  #3 
Geez Lori,
 
I don't know anything about that chemo combo.  I'm sure Edge will.
 
I'm saddened and pissed off to read about your lung area nodes. What the heck!!
 
I think I read that Ixempra was very powerful.  Well, that's what we need right now.  Something to really kick butt.
 
I'm here for you if you need anything ... just let me know.
 
love ya,
Bren
CherylG

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Reply with quote  #4 

So sorry Lori... I know nothing about that chemo mix but wish you all the best.


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Indigoblue

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Reply with quote  #5 
Dear Lori,
 
I don't know what to say...I was weeping for everyone I know going through this breast cancer,  and being always so valiant, brave and courageous.  It's not right; it's not right. 
 
I am sorry to read this "verdict", coming from you.  Remember, some women with mets can go on twenty years, especially with many of the new treatments.  The Ixempra is an exciting, new and what appears to be successful in many clinical trials. 
 
I think Constantine has something about it here or at his website which is enlightening and positive for those of us who are triple negative or facing new mets. 
 
You are in my heart, prayers and many gentle ((((hugs)))).
 
love,
 
Indi
 
 
FLLoriK

Angel
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Reply with quote  #6 

Please share Edge's website wth me. I would like to see it. Thanks! 

FLLoriK

Angel
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Reply with quote  #7 

Since I haven't gotten a start date for chemo, I am not freaking out YET!!!

Fancy

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Angel
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Reply with quote  #8 
Loi, dear, hugs to you.  I know you'll get through this.  Good luck to us all. 

Click on Edge's name anywhere.  His website is listed in his profile.


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Naniam

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Reply with quote  #9 
Lori,

Like others, I know nothing about the drug but wanted to let you know that  I am truly sorry to hear this news.

Love to you and wrapping you in prayers, love and support. 

Brenda
Indigoblue

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Reply with quote  #10 
Hi Lori,

The CHEMOTHERAPY FORUM has some discussion about Ixempra, it's the first subject on the list with Lizsw...I am still search for addition information...I know it's here someplace; also at Triplenegative.com and BCO.org.  There are discussions about Avastin and Parp Inhibitors here, as well.  Just type in SEARCH and it will take you to the topic you are search for on most forums.

Hope it helps.  Still looking...

love,

Indi
edge

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Reply with quote  #11 

Lori:

I addressed the epothilone agent ixabepilone (Ixempra) fully in the thread Which Chemo Should I do? which you had initiated as a query to me back at the beginning of this month, following up an earlier discussion generated by my contribution to the thread you initiated in February on Gemzar and Navelbine, and also a bit after that in March on Gemzar. It is also discussed more technically in my two-part New Appreciation of Triple Negative Disease which you can located as pinned contributions in The Cutting Edge category (Part 1, Part 2), and also published as Issue 3 of my Breast Cancer Watch Digest newsletter. Clicking on the preceding links will take you to these full discussions. Finally, there is actually a not bad Ixempra Patient Information Kit from the FDA (you can download by clicking the preceding link).

As for tamoxifen, as I have already indicated I would not consider that optimal endocrine therapy for a strongly hormone-positive patient such as yourself (and you already were on it back in 2005 as I recall): again subject to knowing more about your clinical history, it strikes me that the AI
letrozole (Femara) which you haven't been exposed to or the pure antiestrogen fulvestrant (Faslodex) are more promising and aggressive endocrine options at this stage.

Finally, given the pattern, type (hepatic, bony and nodal), and velocity of your metastatic disease and progression, ideally I would like to see you on
triplet chemoendocrine therapy consisting of (1) doublet chemotherapy via an ixabepilone (Ixempra) + chemotherapy backbone, initially Ixempra + Xeloda which this can be migrated to Ixempra + Abraxane if the radiological and/or tumor biomarker monitoring motivates that, PLUS (2) an endocrine agent as I indicated and outlined above (letrozole (Femara) or fulvestrant (Faslodex)). And I would be very much surprised if great endocrine expert Charles Vogel who I strongly recommended to your attention, or a leading expert of metatstatic disease like Joyce O'Shaughnessy at US Oncology wouldn't concur with comparably aggressive intervention such as my guidance here.


Constantine Kaniklidis
Breast Cancer Watch
edge@evidencewatch.com

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