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edge

Chief of Research
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Reply with quote  #21 
Coco:


Brevail is a proprietary extract of (North American) flaxseed (Linum usitatissimum) with the lignan known as SDG (secoisolariciresinol diglucoside), along with several other ingredients (Vitamin D3 (400 IU), pinoresinol diglycoside, caffeic acid, ferulic acid and coumaric acid).  Although the manufacturer (Lignan Research) claims that "flaxseed lignan SDG exerts effects similar to the anti-estrogen drug tamoxifen with an apparently much greater degree of tolerability", there is no reliable human clinical evidence to support this, and the scientific validation cited by the company is constituted by preclinical in vitro and in vivo studies of SDG (and not of Brevail itself), and the preclinical evidence is insufficient to support efficacy in humans and in the special class of women with breast cancer. 
 
And although lignans are generally thought to be safe, data on anti-tumor efficacy is not wholly consistent (the just published large Swedish cohort study from Maria Hedelin at Karolisnska and her colleagues examined the activity of isoflavonoids, lignans, and coumestrol, and found no association between intake of isoflavonoids or lignans and breast cancer risk), although there is still a non-dispositive weighting of the balance of the evidence on the side of some potential modest benefit.  But even if there were some benefit of lignans and SDG in breast cancer risk reduction, there is no evidence of clinical efficacy of Brevail in the treatment of active breast carcinoma and claims that "flaxseed lignan SDG exerts effects similar to the anti-estrogen drug tamoxifen" lack scientific support in the clinic, so Brevail cannot be in any way construed as a substitute for tamoxifen, and any suggestion to the contrary, as hinted at in the manufacturer's literature, is reckless. 
 

Constantine Kaniklidis
Breast Cancer Watch
edge@evidencewatch.com

coco

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Goddess
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Reply with quote  #22 
Thank you, Edge, for stearing me clear. Your expertise is invaluable.


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