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edge

Chief of Research
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Posts: 1,129
Reply with quote  #101 

Jason:

 

Sorry your posting slipped by me, so an overdue response. 

 

HD-D3 Optimal Levels

First, as to the optimal dosing for Vitamin D3.  There is a broad rule of thumb: 2000 IUs for bone health, 3000 IUs for anti-tumor activity, but these are merely rough heuristics, and the best way to determine the optimal level for antitumor benefit is through a simple 25(OH)D (Vitamin D3) assay (known by most laboratories as the "25-Hydroxy Vitamin D" test or assay).  Aim for a target level for 25(OH)D of at least 50+ ng/ml for optimal antitumor benefit in breast cancer (remembering that each 1000 IUs of Vitamin D elevates serum 25(OH)D levels approximately 10 ng/ml above base), especially for women with active malignancies, and/or those at elevated risk of malignancy, recurrence, or metastasis.

 

CAM Regimen

Here are my thoughts on the CAM selections:

 

  • Curcumin:  The LEF Super Curcumin is a good formulation, although the Doctor's Best Best Curcumin and Jarrow Formulas Curcumin 95 products from Vitacost.com, and the Now Foods Curcumin from iHerb.com are somewhat more affordable once you equalize dosing.
  • EGCG:  Similarly for the LEF Mega Green Tea Extract - the NSI Green Tea Extract (300 capsules) from Vitacost.com, or Now Foods EGCG Green Tea Extract from iHerb.com are again somewhat more affordable once dosing is equalized.
  • Resveratrol: As near as I can make out the LEF Whole Grape Extract formulation - which is not very near, as I find it almost incoherent (the cited ORAC values for instance are valueless) - the NSI Resveratrol + Grape Seed & Red Wine Extract from Vitacost.com would appear as good and a lot more affordable.

 

But the LEF preparations are still respectable ones, and more than satisfactory in m the context of CAM interventions.

 

Constantine Kaniklidis
Breast Cancer Watch
edge@evidencewatch.com

jason222

Wonderful Son
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Posts: 58
Reply with quote  #102 
Hi Constantine,

Thanks for the guide. I plan to order the online Vit D. test that is offered from the Vitamin D council website soon.

I tried to get the curcumin from vitacost, but they do not provide shipping to my country.

Thanks a lot for your guidance, I hope that everything will sail smoothly from here onwards. And I'll definitely be looking at your CAM webpage for more updates.

MsBliss

Goddess
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Posts: 103
Reply with quote  #103 
My pathology report says p53 (BP-53-11) is high 3+.  Does that mean the mutated version or not?  How are we supposed to find this meaning?

Quote:
Originally Posted by nosurrender
Dear Jason, I am unfamiliar with the health care system of South East Asia. Are you in Japan? We have a wonderful member here who is from Japan and maybe she can help point you in the right direction.

If not, the fact that Taxol is weekly doesn't mean it is weekly for an indefinite amount of time. From what you described, she will probably get 8 or 2 weeks of it. That is standard of care here in North America and I believe Europe as well. So hopefully it is standard of care for you too.

The fact that they are even testing the P53 expression in your mom means that you are at an advanced cancer center. Many places here in the US don't even check for that.

When the P53 gene is functioning normally it is a tumor suppressor. But if it has mutated, then it can increase cancer growth. You need to ask your mom's doctor if she has an over expression of  normal P53 or of mutated P53.  That should also help guide treatment decisions.



nosurrender

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Reply with quote  #104 
MsBliss,
I don't know the answer to that one.
You should ask your onc.
I am not familiar with that rating system.
hugs to you
g


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WE WILL PREVAIL





edge

Chief of Research
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Posts: 1,129
Reply with quote  #105 

MsBliss

 

The Sgnificance of P53-Positivity:

 

Although the prognostic significance of the p53-specific pathway of growth control has not been wholly settled to date, with Martine Piccart's team having analyzed p53 trials before 2005, and finding no association in the majority of them. However,  although not dispositive on the issue, my review of the entire research database to date (pre-2005  and post-2005, including several studies pending publication), finds the weight of the evidence supporting the adverse prognostic significance of p53-positivity, and  this has most recently been confirmed by the review by Byung Joo Chae's team.  They found that p53 status could be a specific prognostic factor in specifically TNBC patients treated by adjuvant anthracycline-based regimen, with p53 (that is, p53-negativity when shown in a pathological report) strongly predictive for relapse-free survival and overall survival. In sum and specifically, with (high) p53-positivity (indicative of a mutated / compromised p53 tumor suppressor gene) we can expect compromised survival, prompting aggressive treatment.

 

Of course remember that any one factor is not decisive, as we have to weigh the collection of all favorable prognostic factors against the collection of potentially prognostically adverse factors, and from that try to discern the balance of overall weighted prognosis and risk, per each unique individual case. 

 

I will be completing my full  discussion for you shortly, and transmitting it to you  within the next couple of days.  Apologies for the unavoidable delay to date.

 


 

Connstantine Kaniklidis

Breast Cancer Watch

edge@evidencewatch.com  

Limner

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Pathfinder Angel
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Posts: 716
Reply with quote  #106 
Oh, fine, just another waterfall to swim up.  My p53 was 100% last September.  Would this ever improve with treatment, Constantine?  Perhaps a few more green leafy vegetables?  Would the lymphoma crank up the p53 also?  I feel great, actually . Looking forward to the rest of your synthesis on this topic -  Many thanks- Mary

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