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MsBliss

Goddess
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Posts: 103
Reply with quote  #1 
Constantine, have you heard of IPT?  It is a method of low dose chemotherapy which utilizes insulin as a optimizer.  It is not broadly used, and in some circles, considered quackery.  But it looks curious and I wonder if it has been dismissed too quickly because it potentiates the use of less patented/pricey chemo drugs.  There is a clinic in Arizona that is run by an ocologist and I can forward the site info or IPT info for your insightful comment.
edge

Chief of Research
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Posts: 1,129
Reply with quote  #2 

MsBliss:

 

Re IPT, developed in Mexico back in the 1930's by Dr. Donato Perez Garcia and now most heavily  promoted by Dr. Stephan Ayre, uses insulin as a supposed adjunct potentiator of chemotherapy and agent, based on a putative enhanced sensitivity of cancer cells to insulin and insulin-like growth factor (IGF), with the additional claim that insulin increases the cell membrane permeability, hence increasing the intracellular concentration and cytotoxic effect of anticancer drugs.  But there is no methodologically reliable and robust clinical evidence for these supporting claims, not for the therapeutic efficacy of IPT in any cancer, and it remains  to  date lacking proven or scientifically validated benefit, and indeed I should note circulating concentrations of IGF-I and IGFBP-3 are actually associated increased, not decreased, risk of many common cancers (including breast cancer).  Therefore, I have to conclude that IPT lacks any significant evidence of potential benefit in breast cancer, and may in the alternative have some propensity for harm. 

 


Constantine Kaniklidis

Breast Cancer Watch

edge@evidencewatch.com  

MsBliss

Goddess
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Posts: 103
Reply with quote  #3 
Thank you, Edge.  
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