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SoCalLisa

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Reply with quote  #1 
I was just wondering if there is any new research indicating how long to take AIs..???

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mrsb

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Reply with quote  #2 
Hi I too wonder as i posted  else  where .  do a google search for protocol B-42 which should link to thew NSABp clinical trials.Protocol B-42
A Clinical Trial to Determine the Efficacy of Five Years of Letrozole Compared to Placebo in Patients Completing Five Years of Hormonal Therapy Consisting of an Aromatase Inhibitor (AI) or Tamoxifen Followed by an AI in Prolonging Disease-Free Survival in Postmenopausal Women with Hormone Receptor Positive Breast Cancer

Specific Aim
To determine whether or not prolonged adjuvant hormonal therapy with letrozole will improve disease-free survival in postmenopausal women with ER-positive and/or PgR-positive tumors who have completed 5 years of hormonal therapy with 5 years of an aromatase inhibitor (AI) or 5 years of a combination of up to 3 years of tamoxifen followed by an AI.



Also http://www.clinicaltrials.gov has anotherNCT00553410
sorry i am not really good with the copy paste etc. but this might help. I am meant to finish my 5yrs this month. I used Tamaxefen 5 months then was switched to AI as I got a blood clot. I have meeting with the oncologist next month but if she doesn't agree my family Dr will look at continuing for me.I am hoping Constantine will join the conversation here as I reallyhave enjoyed reading his input here. Mrs B
nosurrender

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Reply with quote  #3 
Hi,
Constantine will be back later I am sure. He is quite busy at the moment.
Believe it or not, I think my onc is studying this right now!
I have to find out where this is because the study is out of the hospital system I use. My onc is a big researcher who did the work on dose dense chemo.

I will send Constantine a note and I will check on my own onc.

I would LOVE to get in the study if he is running it since I just started my Femara two nights ago.

hugs,
g


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nosurrender

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Reply with quote  #4 
Mrs. B. I have a blood clotting disorder called Protein S Deficiency and my onc told me I would be at a risk of 45-50% of getting a blood clot from tamox.
That is why I am on the Lupron and Femara.

Have you ever had your blood checked for deficiencies? I have to take Plavix every day. I had a retinal blood clot about 4 years ago which is when I was put on the Plavix.

Hugs to you,
g


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BMD

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Reply with quote  #5 

My onc told me this week that by the time I hit 5 years (in 4 years) they should know if I will need to continue my Femara. Her personal opinion is that staying on the meds is keeping the cancer away so why not stay on them.


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BrendaBMD
mrsb

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Reply with quote  #6 
Hi everyone  was just at a Canadian Cancer society conference this weekend and I asked the oncologist who gave a talk what if any trials there were looking at continuing AI for more than 5 years apart from the Protocol B42 that I mentioned there is another called MA17R so there is obviously some thinking along these lines.
Yes Gina all my testing has come back negative on 3 occasions for Leg blood clots .All the best everyone will continue on posting on this subject as i get more info.Mrs B
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