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Calico

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Goddess Forever
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Reply with quote  #1 
Constantine,
I am wondering if it is possible to get a heart rythm abnormality from 4 months of Boniva? My 16 yr old daughter took it due to a synovial tumor (PVNS) destroying her hip. She has a partial hip replacement (BHR) and they want her femoral neck to strengthen. It did on one side with exercise, but got less on the other ....go figure...

(She has a sinus arrythmia that wasn't there 2 yrs ago, but this can be normal for teenagers....having both EKG's to compare I wonder how normal this is from totally normal at 14 to arrythmia at 16....oh well....)

Doc wants Boniva again but based what I read from your research (did I tell you that you are worth your weight in Gold???) I told her my thoughts and she has no problems to switch her to Fosamax. Especially since my daughter had severe side effects everytime she took it. With Fosamax this might be less due to weekly administration vs. full dose monthly Boniva.
Her kidneys were fine so far. She get's 650 mg Citracal plus 3000 D3.

I also probably am looking at taking it myself, I had over 9 % loss in lumbar spine last year and am waiting for results of todays DEXA to see if there is progress with bone loss...I hope not. Been faithfully taking my calcium and vit. D.

I know how bussy you must be and I appreciate your help so very much.
Thank you!!!

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edge

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Reply with quote  #2 

Calico:

 

Thanks much  for the kind words!

 

There is a controversy raging about the effect of bisphosphonates on the heart, in the wake of several studies suggesting an association with atrial fibrillation, and although a study just reported at EULAR in June reported no excess risk with ibandronate (Boniva), I am not wholly convinced given some methodological issues, and similarly the FDA continues to study the problem and has not rescinded it's early warning about this potential risk issued last year.  (I occasionally hear of cardiac rhythm disorders in teens mainly in those with allergic rhinitis or frequent common colds, as they may use OTC medications that contain pseudoephedrine or phenylephrine (PE), which are cardiac stimulants and can sometimes induce arrhythmias).   

 

But be that as it may, you are correct that both alendronate (Fosamax) and risedronate (Actonel) would in any case  be better choices than ibandronate (Boniva).  It may however be prudent for someone with any rhythm dysfunction to  consider a OFA (omega-3 fatty acids) supplement, as OFAs are of demonstrable anti-arrhythmic activity.  To benefit, the EPA + DHA content must be at least 1 gram daily (one good formulation is NSI Mega EFA Omega -3 EPA & DHA available from Vitacost.com, at two capsules daily).  For more severe forms, namely true active atrial flutter or atrial fibrillation, I would advise to also add CoQ10 +  Hawthorn (Now Foods label) during bisphosphonate therapy, but this would not seem necessary at this point in your daughter's case.

 


Constantine Kaniklidis
Breast Cancer Watch
edge@evidencewatch.com  

Calico

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Goddess Forever
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Reply with quote  #3 
Thank you so much for your thoughts on the bisphonates.

She does not have allergies and doesn't take anything else.
She is on fish oil since two years, it made a difference with the pain and I also gave her Turmeric, had stopped that for the recent surgery and will pick that up again.
I will look for I like the NOW brandCO10 + Hawthorn.
Just doesn't feel right to put somebody so young on Fosamax. But hopefully, it helps...it won't be forever.

I appreciate all your help, thank you!

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~ There are lies, damned lies and statistics ~
edge

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Reply with quote  #4 

Calico:

 

The Now Foods CoQ10 + Hawthorn is frightfully expensive (about $70 for 180 capsules, 100mg of CoQ10 and 400mg hawthorn), but the best discount is from AllStarHealth.com (click to go) for about $28.  Maximal dose is 3 daily, but this can be graduated down to one daily once there is an appreciable benefit.  Good luck.

 


Constantine Kaniklidis
Breast Cancer Watch
edge@evidencewatch.com 

Calico

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Goddess Forever
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Reply with quote  #5 
Holy Moly Constantine,
thanks for the 'warning' and discount advise

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