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MicheleS

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Reply with quote  #1 
I just wanted to post here about Edge's CAM reccs.  I'm TN and am desperate to prevent mets... I'm a real worrier and "type-A" personality so the end of active treatment will be stressful for me.

So... I read Edge's reccs very carefully and I followed up with some lit searches of my own.  Then, I took my list to my oncologist for his opinion(s). 

My oncologist already is on board with Vit D.  My levels were checked weeks ago (and were low) so after I take the Rx D3 for 2 months... I'll be on 2000-3000 IU per day. 

He said that every TN should take boswellia, hand's down.  He said he recc's it to his patients at the end of chemo but that I beat him to it. 

Regarding curcumin, resveratrol, and ECGC; he said that he felt that the literature supported those but that there wasn't the obvious benefit that boswellia has... But, he said that if he were me, he would take them.

So... based on my lit search and the recc's of my MD, Edge is right on target (not that you needed me to tell you that!!!).

Also, both my MD and I would add CoQ10 to the list.  There are several fairly broad studies indicating that CoQ10 can help to prevent recurrance.  Some MD's recc taking it during chemo (to prevent the cardiac damage due to Adriamycin), but mine is not one of them.

So, Edge... what's your take on CoQ10?  Any opinions on it?

I'd also add flaxmeal to the list based on animal studies.  My oncologist said that it wouldn't hurt but that the literature in humans just isn't there. 

So that's it!  Just several more reason's to value Edge's input!
Michele

edited to add Culturelle or Acidophilous (sp??) Pearls to my list.  I don't know anything linked to reduction in recurrance with these but active cultures can reduce inflammation and it goes to follow that when you reduce inflammation, you reduce cancer risk.


nosurrender

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Reply with quote  #2 
Michele I just love this post!

All I can add is
YEAH BABY!!!!!


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mrsb

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Reply with quote  #3 
Hi Michelle thanks for posting this. I am not TN but I had been trying to come off the proton inhibitors(as I am on Femara) but had such a bad reaction to the newest one. I figured that there had to be a more natural way of dealing with the acid reflux. I made an appointment with a trusted and highly recommended Natropath and took in a copy of the CAM regime .I wanted to start the supplements but had trouble getting them in Canada .I had other concerns low energy etc but really wanted some support with starting the Regime. I started off with digestive enzymes, Melantoin and COQ100. within a week I was having more energy..actually felt interest in doing more. 3 weeks later I was back at the gym 3 times a week, enrolled in TOPS and walking a mile a day. I returned to the Natropath today to get some more of the recommended supplements and it turns out i am egg and sugar intolerant too.I am really excited about starting this regime. It is so wonderful that this was Constantine's gift to us and finally the oncologists are supporting this...Here in Canada we are not followed by an onclogist after a few years our poor family Drs muddle though our aftercare. This board sis invaluable as i have the best of research to take in with me when i see my famaily Dr and have to advocate for myself.Cheers everyone Shelagh
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Reply with quote  #4 

 

Michele and mrsb / Shelagh:

 

Thanks  for the kind  and generous appreciation.  And nice work, Michele and Shelagh - and never lose an oncologist who displays such open-mindedness and knowledge re integrative oncology (traditional + CAM); it is rare and so to be rarely  valued.

 

Here's some thoughts on the matters raised:

 

  1. With respect  to  boswellic acids (BA) / AKBA, remember that they should always be consumed with a high-fat meal (a healthy couple of tablespoons of olive oil will suffice, along with a full meal) to maximize bioavailability: Vanessa Sterk at the University of Ulm showed that  administration of AKBA in conjunction with a high-fat meal yielded a maximum plasma concentration for AKBA of 6.0 ng/mL for the fasting group versus an amazing 28.8 ng/mL for the high-fat meal group, an improvement in bioavailability of at least four times the normal rate.
  2. Although the data on boswellic acids / AKBA is  robust, the data on curcumin, EGCG, and resveratrol is vastly more extensive by an order of magnitude of at least  a hundred times (curcumin by over a thousand times, being the single most studied CAM agent in history), with benefits reaching more critical underlying molecular pathways and applying confirmably  across dozens of malignancies.  But hierarchy doesn't matter: they are all of exceptional benefit, and more so when their cross-agent synergies are leveraged by co-consumption.
  3. As to CoQ10, several points. 
    • First, CoQ10 is already part of  my Edge-CAM regimen, and has been for well over a year, but it is circumscribed as CoQ10-RN and as I note, narrowly for endocrine-positive disease,  especially when co-consumed  with tamoxifen  where, as demonstrated by Sachdanandam Panchanatham at the University of Madras reporting out at SABCS 2007,  it  effected a reduction of the risk of both cancer recurrence and metastases.
    • Second re CoQ10, the cumulative evidence data does not support verified applicability beyond the endocrine-tamoxifen domain: the broader original studies in 1994 and 1995 were all done by the same team (under Knud Lockwood, who is a principle of  TumorX which  sells the product BioEnerGenics CoQ10), and the studies are unconvincing as  they  are not controlled or randomized,  and in over 15 years  since their publication, there has been no independent confirmation (surprising given the literally billions of doses consumed annually across  the world); given this, I stand by the narrow recommendation I  have already  made in my regimen.  However, as there is no harm from CoQ10, elective consumption is uncontroversial. 
    • Both melatonin (at high-dose 20mg) and CoQ10 are cardioprotective against anthracycline cardiotoxicity, but the CoQ10 benefit is  significantly enhanced when coadministered with Hawthorn extract  (in a 1:4 ratio - 100mg CoQ10 to  400mg  Hawthorn).  The only affordable CoQ10-Hawthorn appears to be under the Now Foods  label, and only from AllStarHealth ($28 for 180, otherwise $70 elsewhere). 
  1. Probiotics like acidophilus are on the side of  the angels as they say (take them myself), but I include in my  regimen only agents with effective and safe anti-tumor (cancer cell eradicative) or anti-tumorigenic (blocking the development of a tumor in the first  place) activities, with sufficient in vivo or better robust, independently cross-confirmed, and methodologically sound cumulative evidence, and with no significant potential for adverse drug interactions via their pharmacokinetics, and which have survived my systematic review and critical appraisal, making for a small but elite company.
  2. AS to acid  reflux / GERD, the natural licorice-derived agent DGL (preferably sugarless, under the Enzymatic label)  can be highly effective (even protecting against the GI-erosive effects of  NSAIDs), and can be coupled with over-the-counter Gaviscon.

 

The regimen will be undergoing some significant revision in the near future.

 


Constantine Kaniklidis

Breast Cancer  Watch

edge@evidencewatch.com

MicheleS

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Reply with quote  #5 
Hey~ Don't revise it too much!  I just placed a HUGE vitacost order! LOL!!! 

Thanks for all of the input, Edge.  You are such a welcome resource for those of us fearful of recurrence. You give us something tangible to DO.  And, your lifestyle reccs are also not lost on me.  I really miss my exercise regimen and am looking forward to pounding the pavement again once chemo is over...

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