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nosurrender

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Reply with quote  #1 
My sister swears by it, but I have to check it against our EdgeCam and also against all the Femara interactions etc....

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edge

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Reply with quote  #2 

It is one of the "good guys" (or girls): I have frequently suggested the  potential benefits, and safety, of l-carnitine and its related compound acetyl-l-carnitine (ALC), as in my recommendations for its potential benefit against chemotherapy-induced neurotoxicity / neuropathy.  It is necessarily not part of my Edge-CAM regimen, not a negative reflection at all, since that is restricted to anticancer CAM component, while L-carnitine and ALC are primarily  part, not of clinical therapeutics, but of what's called supportive oncology, where they justifiable occupy a distinguished position. These agents play a relevant role in energy metabolism and stress response, as a  a role as modulator of cellular stress response, and as a powerful anti-inflammatory agent. 


Let me say that interest has centered around three critical areas of potential application, in treating or protecting against:

 

(1) chemotherapy-induced cardiotoxicity (especially from anthracyclines);

(2) chemotherapy-induced neurotoxicity / neuropathy, especially by platinums; 

(3) chemotherapy-induced fatigue; 

(4) cancer cachexia (a multifaceted and complex metabolic  syndrome characterized, among many symptoms, by extensive muscle wasting, fatigue, and nutritional compromise);

 

and in:

 

(5) enhancing the antitumor potential of platinum compounds;

(6) ameliorating the toxicity of radiotherapy.

 

To date, there is  no evidence of any adverse interaction with any active therapy and in all these cases we have plausible or better evidence of benefit, with increasing human clinical data for several of these benefits. Given that its safety is well-established (carnitine may be safely administered orally at doses up to 3,000 mg/day (Cruciani et al.)), and side effects  are rare and limited primarily to mild gastrointestinal effects (nausea and vomiting), use of carnitine-based supplementation during active therapy appears both safe and of potential benefit in a number of different circumstances, as sketched above. 


[Claudio Pisano and colleagues in Italy; Giulia Gramignano and colleagues in Italy; Ricardo Cruciani and colleagues at Beth Israel; Renata Silvério and colleagues in São Paulo and Rome; Hung-Hsin Chao and colleagues in Taiwan; Mohamed M. Sayed-Ahmed and colleagues in Riyadh; Othman Alshabanah and colleagues in Riyadh; Dilek Gunes and colleagues in Turkey; among many others].



Constantine Kaniklidis

Breast Cancer Watch

edge@evidencewatch.com

edge

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Reply with quote  #3 
By the bye, I should have mentioned that I am considering developing a special version, an Edge-CAM-Support, for agents exhibiting probable benefit in supportive oncology.

For example, for benefit against neuropathy, chemotherapy-induced nausea and vomiting (CINV), chemotherapy-induced fatigue, hand-foot syndrome (HFS), "chemobrain" (chemotherapy-induced cognitive impairment), chemotherapy-induced alopecia (hair loss), cardiotoxicity, radiotoxicity, AI-induced arthralgia/myalgia, and antiestrogen-induced vasomotor symptoms (hot flashes, vaginal atrophy), among others, as an adjunct document to my Edge-CAM regimen (which is really "Edge-CAM-Therapy").


Constantine Kaniklidis

Breast Cancer Watch

edge@evidencewatch.com


nosurrender

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Reply with quote  #4 
Thank you, Edgy. I don't think I can take it with the Thyroid meds ... right?

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Calico

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Reply with quote  #5 
Constantine,
I look forward to more research from you, thank you!! Can't imagine to top what you already provide to us.
Btw, I would love a new brain....I sat in front of google the other day and forgot what I wanted to google.....so....if I could google what I forgot, that would be cool
Also, had some notes in front of the monitor and tried to get the cursor down to my note pad .....do I need to say more??
Need to triple my Curcumin I guess....it suppose to be good for Alzheimers....or maybe I should get micro chipped?

Thank you Edgy, that is essentially what I came here to say!!

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edge

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Reply with quote  #6 

Gina:


Good point.  Yes, l-carnitine is a thyroid antagonist, reducing thyroid levels and so should be avoided by hypothyroid patients on active thyroid therapy or supplementation. 


As the the opposite  condition, of hyperthyroidism, l-carnitine is effective in both reversing and preventing symptoms of hyperthyroidism, along with a favorable beneficial effect on bone mineralization in the form of increased BMD.  In that case (hyperthyroidism), l-carnitine is of positive benefit since it is known that the state of hyperthyroidism depletes the body deposits of carnitine.



Constantine Kaniklidis

Breast Cancer Watch

edge@evidencewatch.com

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Reply with quote  #7 
Calico:

You may need an ungoogle search.  And I agree it is such a nuisance that the cursor doesn't extend past the screen!

Thanks Calico for your always kind words.

And yes, as to memory function and protection against cognitive impairment, and neurodegenerative disorders, curcumin has considerable supporting data.

An "Edge-CAM-Brain" regimen would include higher doses  of, especially:

  • curcuminoids
  • EGCG
  • melatonin
all three of the most appreciable evidenced potential benefit, as well as:
  • DHA
  • the "triple-Gs", namely: gingerols, ginsenosides, and ginkgo
along with
  • Vitamin D3
  • chromium
  • rhodiola
  • food agents: concord grape juice, saffron, and olive oil
  • aromatherapy, especially with lavender oil 
Then let's see what that pesky cursor does!


Constantine Kaniklidis

Breast Cancer Watch

edge@evidencewatch.com



Calico

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Reply with quote  #8 
Ha,
ever the optimist, eh??  

I will google rhodiola, which I'm not familiar with, many thanks. Glad for mouse developers and the 'copy paste' function  

My cat loves the cursor too. He also does not understand why it isn't leaving the screen 




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edge

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Reply with quote  #9 
Calico:

These are mysteries, of cursors and cats!

Rhodiola rosea supplementation improves physical endurance as well as mental performance and acuity, while reducing stress-induced fatigue and with preliminary evidence of efficacy against generalized anxiety disorder (GAD) and related disorders, and with plausible evidence of significant cardioprotection and antidepressant activity, and preliminary but growing evidence of anticancer benefit.  Optimal rhodiola rosea complex requires highly demanding standardization (standardized on rosavins, salidrosides, beta-vicianosides, rosins, rosarins, and polyphenols), to my knowledge only one commercial product meets the requirements, namely Nature's Plus Herbal Actives Rhodiola Extended Release at one daily.

Good luck.


Constantine Kaniklidis

Breast Cancer Watch

edge@evidencewatch.com



Calico

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Reply with quote  #10 
Thank you Constantine.
I'm probably in the wrong thread but wanted to ask about Parthenolide.
I never get the exact dosage due to percentage of extract being important but not the milligram of the product ;( (not sure if I make sense to you, ha!)
How much of this Parthenolide would I have to use? Just one?
It seems more affordable than the Solaray brand...but then, confused on how much to use, if it is a reliable brand, which determines the price per pill, right?




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Calico

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Reply with quote  #11 
Constantine,
I ordered Rhodiola today, there is hope lol

Ordered the NOW brand and it is standardized, will 2 capsules a day be enough?
Rhodiola (Rhodiola rosea) Extract(Root) (standardized to min. 3% Total Rosavins and min. 1% Salidrosides)

Also, regarding my previous post, it is actually 40 mg Parthenolide, not 20 as the label shows...makes it a better value. So far I tolerate that one well and ordered another bottle from Swanson, they have a sale going on.
Many Thanks Constantine!!!

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