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nosurrender

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Reply with quote  #1 
                                       

LITTLE ROCK, Ark.  â€”  Scientists at the University of Arkansas for Medical Sciences hope to begin clinical trials this spring on a vaccine to prevent the recurrence of breast cancer.

                                                       

If successful, the vaccine would not replace traditional treatment such as chemotherapy and radiation but could be an additional treatment for patients, said Laura Hutchins, the principal investigator, professor of internal medicine, and director of the division of hematology and oncology.

                                                       

Thomas Kieber-Emmons, director of basic breast cancer research at the UAMS Winthrop P. Rockefeller Cancer Institute, said the vaccine was developed over a decade of study on the immune system. He said the key was understanding how different molecules work together to combat disease.

                                                       

Breast cancer cells are covered with molecules, called antigens, that are capable of triggering the production of antibodies that fight breast cancer cells. But the carbohydrate antigens on cancer cells don't stimulate a strong immune system response.

                                                       

Kieber-Emmons and his team came up with an alternative approach with a six-year, $2.9 million grant from the U.S. Department of Defense. They developed peptide antigens that mimic the carbohydrates.

                                                                                                                                                                                                                                                                       

A peptide is a compound consisting of two or more amino acids. The peptide-based vaccine tricks the body into producing antibodies that target both the peptides in the vaccine and the carbohydrates they resemble on the breast cancer cells.

                                                       

The trials will be done in phases. The first phase will last four to six months, and involve women with cancer that is actively spreading and women whose cancer has come back after going into remission. The women will receive five doses of the vaccine.

                                                       

The second phase will last about a year and include women who have had breast cancer but are in remission and considered at high risk of getting it again. The women will have to have been off chemotherapy for at least six months.

                                                       

The number of patients participating in the study hasn't been determined.

                                                       


                                                       


                               

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BMD

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Reply with quote  #2 

That is really encouraging. It sounds like they are actually on to something.


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StacyL

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Reply with quote  #3 
Wouldn't that be something to see in our lifetime, or even benefit one of us here?!! I was so excited to hear this news. Thanks, Gina

Jennine

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Reply with quote  #4 
I'm a hopin and a prayin..

I know it's coming!

Hugs and luv,

Jen

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DoreenF

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Reply with quote  #5 
This sounds incredibly promising ...  I'm very hopeful that this vaccine will be one of the keys to disease that we've been dreaming of.  Can't wait to see the results and will be praying for the women participating in this trial that it knocks their cancer to the curb and prevents it from EVER returning. 

Doreen


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Lesley

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Reply with quote  #6 
are they including triple-negatives?

I will be keeping these women in my prayers...

have they actually started the trial?
nosurrender

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Reply with quote  #7 
I do believe they have started the trials.
And I think it is for both cancers....!


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SapphireSky

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Reply with quote  #8 

Wow....great news! 


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